Studies

IMMUNOLOGY INFLAMMATION

1) Increase in intranuclear nuclear factor kappaB and decrease in inhibitor kappaB in mononuclear cells after a mixed meal: evidence for a proinflammatory effect. Aljada A, Mohanty P, Ghanim H, Abdo T, Tripathy D, Chaudhuri A, Dandona P. Am J Clin Nutr. 2004 Apr;79(4):682-90.Learn More

2) Mouse and human neutrophils induce anaphylaxis. Jönsson F, Mancardi DA, Kita Y, Karasuyama H, Iannascoli B, Van Rooijen N, Shimizu T, Daeron M, Bruhns P. J Clin Invest. (2011) Apr 1;121(4):1484-96.Learn More

3) IgG subclasses and allotypes: from structure to effector functions. GesturVidarsson, Gillian Dekkers and Theo Rispens. Frontiers in Immunology October 2014 | Volume 5 | Article 520 | 1.Learn More

4) Testing for IgG4 against foods is not recommended as a diagnostic tool: EAACI Task Force Report.Steven O. Stapel , R. Asero , B. K. Ballmer-Weber 3 , E. F. Knol , S. Strobel , S. Vieths , J. Kleine-Tebbe Allergy (2008) 63:793–796.Learn More

5) Inhibition of complement activation by IgG4 antibodies. Van der Zee JS, van Swieten P, Aalberse RC. Clin. Exp. Immunol. (1986) May: 64 (2):415-22.Learn More

6) Immunoglobulin G4: an odd antibody. Aalberse RC, Stapel SO, Schuurman J, Rispens T. Clin Exp Allergy, (2009) 39 (4):469-77.Learn More

7) Independent audit of IgG food intolerance tested patient survey. Sheldon TA. British Allergy Foundation, 2000.Learn More

8) Inflammation and metabolic disorders. Hotamisligil G. S. Nature, (2006), 444, 860-867.Learn More

9) Food Allergy: Adverse Reactions to Foods and Food Additives. 4th edition page18
Edited by Dean D. Metcalfe, Hugh A. Sampson, and Ronald A. Simon c 2008 Blackwell Publishing, ISBN: 978-1-405-15129-0.Learn More

10) Gliadin IgG antibodies and circulating immune complexes. Eisenmann A1, Murr C,
Fuchs D, Ledochowski M.Scand J Gastroenterol. 2009; 44(2):168-71.Learn More

IBS

11) Food elimination based on IgG antibodies in irritable bowel syndrome: a randomised controlled trial. Atkinson W, Sheldon TA, Shaath N, Whorwell PJ. Gut. 2004 Oct, 53(10):1459-64. Learn More

12) Food allergy in irritable bowel syndrome: The case of non-celiac wheat sensitivity. Mansueto P,D’Alcamo A, Seidita A1Carroccio AWorld J Gastroenterol. 2015 Jun 21;21(23):7089-109.Learn More

13) Treating irritable bowel syndrome with a food elimination diet followed by food challenge and probiotics. Drisko J., Bischoff B., Hall M., McCullum. J of the Am college of Nutrition 2006. Vol25 (6) 514-522.Learn More

14) Milk protein IgG and igA : the association with milk-induced gastrointestinal symptoms in adults. Anthoni S, Savilahti E, Rautelin H, Kolho KL World J. (2009) Gastroenterol. Oct 21 ; 15 (39) 4915-8.Learn More

15) Serological Investigation of Food Specific Immunoglobulin G Antibodies in Patients with
Inflammatory Bowel Diseases. Chenwen Cai, Jun Shen, Di Zhao, Yuqi Qiao, Antao Xu, Shuang Jin, Zhihua Ran, and Qing Zheng*PLoS One. 2014 Nov 13;9(11).Learn More

16) The value of eliminating foods according to food-specific immunoglobulin G antibodies in irritable bowel syndrome with diarrhea. Hong Guo, Tao Jiang, Jinliang Wang, Yongchao Chang, Hai Guo, Weihong Zhang. J.Int.Med.Res.2012; 40 (1):204-10.Learn More

17) Alterations of food antigen-specific serum immunoglobulins G and E antibodies in patients with irritable bowel syndrome and functional dyspepsia. Zuo X. L., Li Y. Q., Li W. J., Guo Y. T., Lu X. F., Li J. M. and P. V. Desmond Clinical and Experimental Allergy 2007, 37, 823–830.Learn More

18) Immune Activation in patients with irritable bowel syndrome. Liebregts T, Adam B, Bredack C, Röth A, Heinzel S, Lester S, Downie-Doyle S, Smith E, Drew P, Talley NJ, Holtmann G. Gastroenterology. 2007 Mar;132(3):913-20. Epub 2007 Jan 26.Learn More

19) Food allergy in irritable bowel syndrome: new facts and old fallacies. Isolauri E., Rautava S., Kalliomaki M.. Gut 2004; 53 (10):1391-3.Learn More

MIGRAINE

20) Diet restriction in migraine, based on IgG against foods: a clinical double-blind, randomised, crossover trial. Alpay K, Ertas M, Orhan EK, Ustay DK, Lieners C and Baykan B. (2010) Cephalgia 1-9. Learn More

21) IgG-mediated allergy: a new mechanism for migraine attacks? Pascual J, Oterino A. Cephalalgia. 2010 Jul;30(7):777-9. doi: 10.1177/0333102410364856. Epub 2010 Mar 26.Learn More

22) Randomised controlled trial of food elimination diet based on IgG antibodies for the prevention of migraine like headaches. Natasha Mitchell et al, Nutrition Journal 2011.Learn More

23) A prospective Audit of food intolerance among migraine patients in primary care clinical practice. Trevor Rees,David Watson, Susan Lipscombe, Helen Speight, Peter Cousins, Geoffrey Hardman, Andrew Dowson. (2005) Headache, Vol 2 No.1 11-14.

24) Food allergy mediated by IgG antibodies associated with migraine in adults. Arroyave Hernandez CM,Echevarria Pinto M, Hernandez Montiel HL. Rev Alerg Mex (2007);54: 162–168. Learn More

AUTOIMMUNITY

26) Molecular mimicry as a mechanism for food immune reactivities and autoimmunity. Vojdani A .Altern Ther Health Med. 2015;21 Suppl 1:34-45.Learn More

27) Cross-Reaction between Gliadin and Different Food and Tissue Antigens. Aristo Vojdani1,2*, Igal Tarash1 Food and Nutrition Sciences, 2013, 4, 20-32. Learn More

28) Anti-Saccharomyces cerevisiae autoantibodies in autoimmune diseases: from bread baking to autoimmunity. Rinaldi M1, Perricone R, Blank M, Perricone C, Shoenfeld Y.Clin Rev Allergy Immunol.2013 Oct;45(2):152-61. Learn More

29) Gastrointestinal disease in Sjogren’s syndrome: related to food hypersensitivities. Kim-Lee C, Suresh L, Ambrus JL Jr.Springerplus. 2015 Dec 12;4:766. Learn More

30) Lectins, agglutinins, and their roles in autoimmune reactivities.. Vojdani A.Altern Ther Health Med. 2015;21 Suppl 1:46-51. Learn More

31) The gut–joint axis: cross reactive food antibodies inheumatoid arthritis. M Hvatum†,
L Kanerud, R Hällgren, and P Brandtzaeg, Gut. 2006 Sep; 55(9): 1240–1247. Learn More

32) The pathogenesis of rheumatoid arthritis is associated with milk or egg allergy..Li J, Yan H, Chen H, Ji Q, Huang S, Yang P, Liu Z, Yang B. North Am J Med Sci 2016;8:40-6. Learn More

33) Correlation of Tissue Antibodies and Food Immune Reactivity in Randomly Selected Patient Specimens. J Lambert J, Vojdani A (2017) Clin Cell Immunol 8: 521. Doi: 10.4172/2155-9899.1000521. Learn More

CROHN’s DISEASE

34) Higher titers of anti-Saccharomyces cerevisiae antibodies IgA and IgG are associated with more aggressive phenotypes in Romanian patients with Crohn’s disease. Gologan S1, Iacob R, Preda C,Vadan R, Cotruta B, Catuneanu AM, Iacob S, Constantinescu I, Gheorghe L, Iobagiu S, Gheorghe C, Diculescu M. J Gastrointestin Liver Dis. 2012 Mar;21(1):39-44.Learn More

35) The effects of provocation by foods with raised IgG antibodies and additives on the course of Crohn’s disease: A pilot study. Hulya Uzunismail et al. Turk J Gastroenterol 2012; 23 (1): 19-27.Learn More

36) Clinical relevance of IgG antibodies against food antigen in Crohn’s Disease – A double blind cross over diet intervention study. S. Bentz, M. Hausmann, S. Paul, W. Falk, F. Obermeier, J.Scholmerich, G. Rogler Digestion (2010);81:252–264.Learn More

ASTHMA

37) Food-specific IgG Antibody–guided Elimination Diets Followed by Resolution of Asthma
Symptoms and Reduction in Pharmacological Interventions in Two Patients: A Case Report Kulveen Virdee,Glob Adv Health Med. 2015 Jan; 4(1): 62–66.Learn More

38) Ovalbumin-specific immunoglobulin G and subclass responses through the first 5 years of life in relation to duration of egg sensitization and the development of asthma. Vance, G.H.S., Thornton, C.A., Bryant, T.N., Warner, J.A. and Warner, J.O. Clinical and Experimental Allergy,(2004) 34, (10), 1542-1549.Learn More

39) The effect of exclusion of dietary egg and milk in the managment of asthmatic children :
a pilot study. Yussof NA, Hampton SM, Dickerson JW, Morgan JB, (2004) J.R.Soc.Health 124(2) 74-80.Learn More

BRAIN-Psychosis

40) IgG dynamics of dietary antigens point to cerebrospinal fluid barrier or flow dysfunction in firstepisode schizophrenia. Emily G. Severance,a,* Kristin L. Gressitt,a Armin Alaedini,b Cathrin Rohleder,c Frank Enning,c,d J. Malte Bumb,c Juliane K. Muller,c Emanuel Schwarz,c Robert H. Yolken,a and F. Markus Leweke . Brain Behav Immun. 2015 Feb; 44: 148–158.Learn More

41) The humoral response in the pathogenesis of gluten ataxia. M. Hadjivassiliou, MD, Neurology April 23, 2002 vol. 58 no. 8 1221-1226.Learn More

42) Disruption in the Blood-Brain Barrier: The Missing Link between Brain and Body Inflammation in Bipolar Disorder? Jay P. Patel1 and Benicio N. Frey Neural Plasticity Volume 2015, Article ID 708306, 12 pages.Learn More

43) The role of IgG hypersensitivity in the pathogenesis and therapy of depressive disorders.
Karakuła-Juchnowicz H, Szachta P, Opolska A, Morylowska-Topolska J, Gałęcka M, Juchnowicz D, Krukow P, Lasik Z. Nutr Neurosci. 2014 Sep 30.Learn More

44) Evidence for an immune response in major depression: a review and hypothesis.Maes M. Progress in Neuro-Psychopharmacology and Biological Psychiatry 1995 Volume 19, Issue1, Pages11-38.Learn More

45) Subunit and whole molecule specificity of the anti-bovine casein immune response in recent onsetpsychosis and schizophrenia. Severance EG, Dickerson FB, Halling M, Krivogorsky B, Haile L, Yang S, Stallings CR, Origoni AE, Bossis I, Xiao J, Dupont D, Haasnoot W, Yolken RH. Schizophr Res. 2010 May;118(1-3):240-7Learn More

46) Association between bovine casein antibody and new onset schizophrenia among US military personnel. Niehbur DW, Li Y, Cowan DN, Weber NS, Fisher JA, Ford GM, Yolken R. (2011) Schizophr.Res. Mar2. (Epub ahead of print.Learn More

47) Complement C1q formation of immune complexes with milk caseins and wheat glutens in
Schizophrenia. Emily G. Severancea, Kristin Gressitta, Meredith Hallinga, Cassie R. Stallingsb, Andrea E. Origonib, Crystal Vaughanb, Sunil Khushalanib, Armin Alaedinic, Didier Dupontd, Faith B. Dickersonb, and Robert H. Yolkena Neurobiol Dis. 2012 December ; 48(3): 447–453.Learn More

48) Dietary antigens, epitope recognition, and immune complex formation in recent onset psychosis and long-term schizophrenia. Severance EG1, Lin J, Sampson HA, Gimenez G, Dickerson FB, Halling M, Gressitt K, Haile L,Stallings CR, Origoni AE, Dupont D, Yolken RH.Schizophr Res. 2011 Mar;126(1-3):43-50.Learn More

49) Seroreactive marker for inflammatory bowel disease and associations with antibodies to dietary proteins in bipolar disorder. Emily G. Severancea, Kristin L. Gressitta, Shuojia Yanga, Cassie R. Stallingsb, Andrea E. Origonib, Crystal Vaughanb, Sunil Khushalanib, Armin Alaedinic, Faith B. Dickersonb, and Robert H. YolkenaBipolar Disord. 2014 May ; 16(3):230–240.Learn More

50) Gastrointestinal inflammation and associated immune activation in schizophrenia.
Emily G. Severancea, Armin Alaedinib, Shuojia Yanga, Meredith Hallinga, Kristin L. Gressitta, Cassie R. Stallingsc, Andrea E. Origonic, Crystal Vaughanc, Sunil Khushalanid, F. Markus Leweked,e, Faith B. Dickersonc, and Robert H. Yolkena Schizophr Res. 2012 June ; 138(1): 48–53.Learn More

51)Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders. John R. Kelly,Paul J.,.John F. Cryan, Timothy G. Dinan, Gerard Clarke, Niall P. Hyland Front. Cell. Neurosci., 14 October 2015 Learn More

52)Gut Uptake, Brain and Behaviour Tveiten D. Bioeng1 and K. L. Reichelt Journal of Scientific Research &Reports 3(22): 2834-2847, 2014;Learn More

Excema

53) Circulating immunoglobulins, leucocytes and complements in childhood-onset atopic eczema. Hon KL1, Wang SS, Pong NH, Leung TF.Indian J Pediatr. 2013 Feb;80(2):128-31. Learn More

OBESITY

54) Baker’s yeast (Saccharomyces cerevisiae) antigen in obese and normal weight subjects. Salamati S1, Martins C, Kulseng B. Clin Obes. 2015 Feb;5(1):42-7.Learn More

55) IgG Receptor FcγRIIB Plays a Key Role in Obesity-Induced Hypertension.
Nathan C. Sundgren, Wanpen Vongpatanasin, Brigid-Meghan D. Boggan, Keiji Tanigaki, Ivan S. Yuhanna, Ken L. Chambliss, Chieko Mineo, and Philip W. Shaul Hypertension. 2015 February ; 65(2): 456–462.Learn More

56) Antibodies against food antigens are correlated with inflammation and intima media thickness in obese juveniles. Wilders-Truschnig M, Mangge H, Lieners C, Gruber HJ, Mayer C and Marz W. IgG.(2007). Exp Clin Endocrinol Diabetes.Learn More

57) Increase adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. Hotamisligil G. S., Arner P., Caro J. F., Atkinson R. L., Spiegelman B. M.. J Clin Invest (1995); 95: 2409-2415.Learn More

58) Adipose expression of tumor necrosis factor- direct role in obesity-linked insulin resistance. Hotamisligil G. S., Shargill N. S., Spiegelman B. M.. Science (1993); 259: 87-91.Learn More

Autism

59) Food allergy investigations and ist significance in autism spectrum disorders. Anath N Rao, Minakshi Koch, Sabyasachi Ghosh and Suresh Kumar V. International Journal of Pharma and Bio Sciences Vol.1/Issue-4/Oct-Dec.2010.Learn More

60) Antibodies against Food Antigens in Patients with Autistic Spectrum Disorders. Laura de Magistris, Annarita Picardi, Dario Siniscalco, Maria Pia Riccio, Anna Sapone, Rita Cariello, Salvatore Abbadessa, Nicola Medici, Karen M. Lammers, Chiara Schiraldi, Patrizia Iardino, Rosa Marotta, Carlo Tolone, Alessio Fasano, Antonio Pascotto, and Carmela Bravaccio BioMed Research International Volume 2013, Article ID 729349, 11 pages.Learn More